What is / ?

01

What’s in the blend

Two peptides from two research lineages:

• without DAC: a synthetic analogue built on the first 29 amino acids of GHRH, with several amino-acid substitutions.
• : Aib–His–D-2-Nal–D-Phe–Lys–NH2, a pentapeptide from a Novo Nordisk program, described in 1998.

As a blend, it has no single formula. The certificate of analysis for each lot reports the blend.

Sources: [4] Drug Testing and Analysis · 2021 · [5] European Journal of Endocrinology · 1998

02

What “No DAC” means

exists in two versions. DAC, short for drug affinity complex, is a reactive chemical group that attaches the peptide permanently to albumin in the blood.

In two 2006 studies, the DAC version stayed in circulation for about a week, with an estimated half-life of 5.8 to 8.1 days. The version without DAC lacks that group. Anti-doping chemists treat the two as separate compounds.

This blend uses the version without DAC. A label or COA that says “with DAC” describes a different compound.

Sources: [2] Journal of Clinical Endocrinology & Metabolism · 2006 · [3] Journal of Clinical Endocrinology & Metabolism · 2006 · [4] Drug Testing and Analysis · 2021

03

Two receptors, two pathways

is a GHRH analogue, so it acts on the GHRH receptor, the target of the natural hormone first sequenced in 1982.

acts on a different receptor, the one the growth hormone-releasing peptides use. In 1999 its natural ligand was identified as ghrelin, a 28-amino-acid peptide from the stomach.

The 1998 paper used GHRH and GHRP antagonists to show that the pentapeptide works through the GHRP receptor, not the GHRH one. Pairing one of each is the logic of the blend; no study cited here tested this specific blend.

Sources: [1] Science · 1982 · [6] Nature · 1999 · [5] European Journal of Endocrinology · 1998

04

What researchers have studied

Each component has its own literature:

• GHRH and its analogues: growth hormone and IGF-1 secretion.
• The pentapeptide: selective growth hormone release in rats and swine.
• Detection of GHRH analogues in anti-doping laboratories.

These are observations in laboratory models. They are not evidence about any use in people.

Sources: [2] Journal of Clinical Endocrinology & Metabolism · 2006 · [3] Journal of Clinical Endocrinology & Metabolism · 2006 · [5] European Journal of Endocrinology · 1998 · [4] Drug Testing and Analysis · 2021

05

Related compounds

Another GHRH analogue in the catalog, , keeps all 44 residues of the natural hormone: What is ?

For the pentapeptide on its own: What is ?

The unmodified 29-residue fragment of GHRH that was built on: What is ?

06

How it is supplied and stored

ships as a lyophilized (freeze-dried) powder in 5 mg or 10 mg vials. The powder is stable at room temperature in transit. For lab use it is reconstituted with bacteriostatic water such as .

Concentration is total blend content divided by volume: 10 mg in 2 mL gives 5 mg per mL of combined peptide. The reconstitution calculator handles other combinations.

For storage before and after reconstitution, see how to store lyophilized peptides.

07

How to verify a batch

Every lot has its own certificate of analysis from an independent lab. Read three results separately:

• Identity: confirms the expected compound was detected.
• Purity: the share of the measured material that is the intended compound.
• Content: the amount measured, compared with the label.

Then match the lot number on your vial or bottle to the report, and use the report’s verification link to confirm it with the testing lab. Step by step: how to read a peptide COA.