Research library / Compounds

What is peptide?

A seven-residue analogue of an ACTH fragment, with more than two decades of research behind it.

is a synthetic peptide of seven amino acids: Met–Glu–His–Phe–Pro–Gly–Pro. It came out of Russian research on fragments of adrenocorticotropic hormone (ACTH), and it has been studied in neurotrophic research for more than two decades. Prism Labs supplies it as a lyophilized vial.

Prism Labs editorial · Updated October 8, 2026 · 4 min read

Lyophilized vial5mg · 10mg · 99.71% purity$35.99View product

What it is

The sequence is Met–Glu–His–Phe–Pro–Gly–Pro, or MEHFPGP in one-letter code. The first four residues match ACTH(4–7). The last three, Pro–Gly–Pro, extend that fragment, and papers describe the result as a synthetic analogue of ACTH(4–10).

The reference structure has the molecular formula C37H51N9O10S and a molecular weight of 813.9 g/mol (PubChem CID 9811102). Those are reference values; your lot’s certificate of analysis reports what was measured.

Some suppliers sell an N-acetylated, amidated variant. That is a modified molecule with a different formula, so check that the sequence and formula on the COA match what you ordered.

Sources: [3] PubChem · reference structure · [6] Journal of Inorganic Biochemistry · 2016

Where it came from

It grew out of Moscow research groups, including Igor Ashmarin’s, that studied short peptides built from ACTH fragments and ‘glyprolines’ such as Pro–Gly–Pro.

By 2001, papers were reporting rapid changes in neurotrophin RNA in cultured rat glial cells. A 2006 study measured BDNF and its receptor TrkB in the rat hippocampus, and a 2010 follow-up compared the timing of NGF and BDNF gene expression across brain tissues.

Sources: [5] Russian Journal of Physiology · 2001 · [4] Neuroscience Letters · 2001 · [1] Brain Research · 2006 · [2] Journal of Molecular Neuroscience · 2010

Lyophilized vial from Prism Labs — Every lot ships with its own certificate of analysis.

What researchers have studied

Most published work is in rodents and cell cultures, and most of it measures gene expression:

Neurotrophins such as BDNF and NGF, and their receptors.
Immune- and vascular-related genes in rat brain-injury models.
Brain-network activity, in a 2020 study that examined it alongside .

A change in RNA is not the same as a change in protein or behavior, so read each paper for what it actually measured.

These are observations in laboratory models. They are not evidence about any use in people.

Sources: [1] Brain Research · 2006 · [2] Journal of Molecular Neuroscience · 2010 · [7] BMC Genomics · 2014 · [8] Doklady Biological Sciences · 2020

vs

The two are often compared. Both are seven-residue synthetic peptides from the same Russian research tradition, and both end in Pro–Gly–Pro. extends an ACTH fragment (MEHFPGP); extends tuftsin, a four-residue immune peptide (TKPRPGP). A 2020 study examined both in the same brain-network experiments.

Sequences, research literature and formats side by side: vs , compared.

Sources: [8] Doklady Biological Sciences · 2020

How it is supplied and stored

ships as a lyophilized (freeze-dried) powder in 5 mg or 10 mg vials. The powder is stable at room temperature in transit. For lab use it is reconstituted with bacteriostatic water such as .

For a vial, concentration is content divided by volume: 10 mg in 2 mL gives 5 mg per mL. The reconstitution calculator handles other combinations.

For storage before and after reconstitution, see how to store lyophilized peptides.

How to verify a batch

Every lot has its own certificate of analysis from an independent lab. Read three results separately:

Identity: confirms the expected compound was detected.
Purity: the share of the measured material that is the intended compound.
Content: the amount measured, compared with the label.

Then match the lot number on your vial or bottle to the report, and use the report’s verification link to confirm it with the testing lab. Step by step: how to read a peptide COA.